APL-OSA, Beta Version

In the presence of genetic heterogeneity, APL-OSA can identify a genetically homogenous subset of families based on a trait-related covariate. APL-OSA then tests the relationship between the association statistics (i.e., the APL statistics) calculated based on the subset and the family-specific covariate. APL-OSA is based on the OSA method for linkage (Hauser et al. 2004) and the family-based association test, APL (Martin et al. 2003; Chung et al. 2006). Thus, APL-OSA has similar properties with OSA and APL. Bi-alleleic markers such as SNPs are accepted by APL-OSA. APL-OSA is a single-marker test and considers one covariate each time. APL-OSA is written in C++ and is available for Solaris Unix, RedHat Linux, and Windows XP platforms.

Please fill out the form below to download the APL-OSA Program.

If you need APL-OSA for a different Operating System, please contact elizabeth.hauser@duke.edu.