Effect of Preprandial Ghrelin on Postprandial Glucose Tolerance

Principal Investigator: Jenny Tong, MD, MPH

Sponsor: National Institutes of Health

The purpose of this research study is to determine how the hormone acyl ghrelin (a naturally occurring hormone made mostly by the stomach) affects insulin secretion and blood glucose levels after a meal.  The results from this research may help individuals with Type 2 diabetes better manage their glucose levels in the future.

Two study groups will be enrolled in this trial – healthy controls and individuals with Type 2 diabetes.  Participants with Type 2 diabetes will be asked to complete two 4.5-hour testing visits at the Duke Center for Living campus, each requiring an overnight fast followed by the consumption of a standardized breakfast (provided by the study team) 3.5 hours before the mid-morning appointment.  Healthy controls will be asked to complete four of these testing visits.

Type 2 diabetic participants may qualify if:

  • Between the ages of 18 – 70 years
  • Treating diabetes with pills or diet and exercise, but NOT using insulin
  • BMI is 25.0 – 45.0

Healthy participants may qualify if:

  • Between the ages of 18 – 40 years
  • BMI is 18.0 – 29.9

Study volunteers will be compensated for their participation.

For more information, please call (919) 681-9000, press 5 or email LSSResearch@dm.duke.edu.

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