EMK Program, Version 1.0
The EMK program implements two family-based association methods, allele- and genotype- based association methods, that we developed based on the framework of the allele-based method developed by Monks and Kaplan (2000) for quantitative traits (Li et al. 2008). Our version of allele-based EMK (allele-EMK) and genotype-based EMK (geno-EMK) methods are applicable to any pedigree structure, for instance, nuclear families with or without parental genotypes, and extended pedigrees. Currently, EMK program is fit to bi-allelic markers (e.g. single nucleotide polymorphisms).
Li YW, Martin ER, Li YJ (2008) EMK: A Novel Program for Family-Based Allelic and Genotypic Association Tests on Quantitative Traits. Annals of Human Genetics 72 (Pt 3): 388-396. Monks SA and Kaplan NL (2000) Removing the sampling restrictions from family-based tests of association for a quantitative-trait locus. Am J Hum Genet 66:576-592
The EMK software is written in C++ and is available for the Solaris and Windows platforms. Please fill out the form below to download the EMK Program.
Please contact Yi-ju Li if you have any questions.