Svati H. Shah, MD, MHS

Associate Director of Clinical Translation
Duke Molecular Physiology Institute

Position

Associate Professor
Department of Medicine, Division of Cardiology
Duke University Medical Center

Contact

Carmichael Building

919 684 2859

svati.shah@duke.edu

Summary

Svati H. Shah, MD, MHS is Associate Professor of Medicine, Vice-Chief of Translational Research and Associate Director of the Cardiology Fellowship within the Division of Cardiology, Department of Medicine and is Co-Director of Translational Research within the Duke Molecular Physiology Institute. Her research laboratory focuses on the molecular epidemiology of cardiometabolic diseases, using integrated 'omics technologies including genomics and metabolomics, to identify novel biomarkers and mechanisms of disease pathogenesis. 

MHS, Medical Genomics, Duke University, Durham, NC
MD, University of Washington, Seattle, WA
MHS., Johns Hopkins University, Baltimore, MD

My research laboratory studies the molecular epidemiology of cardiovascular disease, utilizing metabolomic, genomic and bioinformatics methods in a "systems biology" approach to identify novel biomarkers and mechanisms of cardiometabolic disease pathogenesis. The laboratory encompasses a statistical analytic component (Lydia Kwee, PhD and Damian Craig, MS), a clinical research component (Dagny Noeth, Melissa Hurdle) as well as a wet lab component for genomic analyses (Megan Chryst-Ladd, Elizabeth Burns). We work on several cardiometabolic phenotypes, including coronary artery disease, acute coronary syndrome, cardiovascular events, aortic stenosis, aortic aneurysm, pulmonary hypertension, type II diabetes, and heart failure, . We are involved in molecular profiling in cardiometabolic cohorts including CATHGEN (N=9500 individuals referred to cardiac catheterization), EPGEN (N=2500 individuals undergoing electrophysiologic procedures); and in clinical trial biorepositories through collaborations with the Duke Clinical Research Institute (DCRI) including Trilogy (clinical trial of acute coronary syndrome), Navigator (clinical trial to prevent transition from prediabetes to diabetes), and PROMISE (clinical trial of imaging in suspected CAD). More recently, we have expanded our molecular epidemiology efforts to identify disease biomarkers in global populations and are currently conducting a small prospective study of metabolic and genomic biomarkers of type II DM and CAD in Gurgaon, India in collaboration with Medanta Hospital through collaborations with the Duke Global Health Institute (DGHI). Through work with the Duke Heart Center, we also care of patients with hereditary cardiovascular disorders in the Duke Adult Cardiovascular Genetics Clinic (Dagny Noeth, genetic counselor). Our work has resulted in the identification of novel CAD genes; metabolic biomarkers that predict incident CVD events; and novel pathways of CVD event pathogenesis.

Staff

Elizabeth Burns

Megan Chryst-Ladd

Damian Craig

Stephanie Giamberardino

Melissa Hurdle

Lydia Kwee, PhD

Postdocs / Fellows

Bethany Doran, MD

Other Research Team Members

Albert Sun, MD

Current Lab Members
Lydia Kwee, PhD
Damian Craig, MS
Melissa Hurdle
Dagny Noeth, CGC
Megan Chryst-Ladd
Elizabeth Burns
Hanghang Wang, MD
Albert Sun, MD

Collaborators
Simon G. Gregory, PhD (Duke)
Elizabeth Hauser, PhD (Duke)
William E. Kraus, MD (Duke)
Christopher B. Newgard, PhD (Duke)
James Bain, PhD (Duke)
Michael Muehlbauer (Duke)
Redford Williams, PhD (Duke)
Geoffrey Ginsburg, MD, PhD (Duke)
Laura Svetkey, MD (Duke)
Patrick Pun, MD (Duke)
L. Kristin Newby, MD (Duke)
Mark Chan, MD (Singapore)
Robert Gerszten, MD (Massachusetts General Hospital)
Sanjay Mittal, MD (Medanta Hospital, India)
Ravi Kasliwal, MD (Medanta Hospital, India)
Jennifer Wu, MD, MPH (UNC)