Role of alpha-cell GLP-1 in the beta-cell response to DPP-4 inhibition

This study is being done to determine the role of a hormone, glucagon-like peptide 1 (GLP-1), on insulin secretion and to study how GLP-1 works in in diabetic individuals as compared to non-diabetic individuals, under fasting conditions.

GLP-1 is a naturally occurring hormone made in the intestines.  It is released into the circulating blood after eating and helps to control the blood glucose levels by increasing insulin secretion by cells in the pancreas.  However, the exact method by which GLP-1 causes insulin secretion and how GLP-1 activity is changed in diabetic persons remain unclear.  This research is being done to address these questions and better understand the function of GLP-1.

We are looking for both diabetic and non-diabetic adults ages 35-70 who are willing to participate in two 4-hour infusion appointments at the Duke Center for Living.  If interested, please call Leslie Kelly at (919) 681-9000, press 3 or email

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