Allison Ashley-Koch, PhD

Faculty Member, Duke Molecular Physiology Institute

Position

Professor, Department of Medicine. Professor in Biostatistics and Bioinformatics

Contact

Carmichael Building

919-684-1805

allison.ashleykoch@duke.edu

Summary

Allison Ashley-Koch, PhD, is a Professor in the Duke Molecular Physiology Institute and the Department of Medicine at Duke University Medical Center. Dr. Ashley-Koch is a genetic epidemiologist whose primary goal is the identification of genes that contribute to human genetic disorders, including the identification of gene-gene and gene-environment interactions. She is currently involved in studies to dissect the genetic etiology of attention deficit hyperactivity disorder (ADHD), autism, chiari type I malformations, essential tremor, and neural tube defects. Additional research foci include genetic modifiers of sickle cell disease, and genetic contributions to birth outcomes, particularly among African American women.

 

 

PhD, Genetics and Molecular Biology, Emory University, Atlanta, GA

Much of Dr. Ashley-Koch's work focuses on disorders of a neurological or psychiatric nature. She is examining the genetic, epigenetic and environmental contributions to neural tube defects (NTDs). One of the NTD projects is examining the potential connection between fumonisin exposure and the occurrence of NTDs in Guatemala.   She also co-directs the largest genetic study of anencephaly world-wide.  Another interest is the genetic etiology of Chiari type I malformation (CMI), with or without syringomyelia, a condition often misdiagnosed because of the clinical presentation. The CMI team is using cranial morphology measurements and gene expression profiles to help identify clinically and genetically homogeneous subsets of CMI patients. Dr. Ashley-Koch is involved in the genetic dissection of several psychiatric genetic conditions, including autism, ADHD, bipolar disorder, depression and post-traumatic stress disorder.

A long-standing interest has been the identification of genetic modifiers for sickle cell disease (SCD). Despite the commonality of the sickle cell mutation, there is a wide range of clinical severity in the disease presentation and her group is identifying the genetic risk factors for these complications.  Her group utilizes in vivo zebrafish models to evaluate the functional significance of genetic risk factors for SCD nephropathy.

Dr. Ashley-Koch’s lab takes a variety of molecular approaches to dissect these diseases, including next generation sequencing technologies, epigenetic methods, genomewide SNP analyses and candidate gene mutation analysis. Dr. Ashley-Koch is also interested in statistical methods development to reduce dimensionality and to identify underlying substructure in genetic data sets.

NHLBI Trans-Omics for Precision Medicine Whole Genome Sequencing Program

Dr. Ashley-Koch and her long-time collaborator, Dr. Marilyn Telen, have contributed their “Outcome Modifying Genes in Sickle Cell Disease” (OMG-SCD) cohort to NHLBI’s TOPMed program. OMG-SCD is a cohort of adult sickle cell disease patients that were collected for the purpose of identifying genetic modifiers of SCD.

Dr. Ashley-Koch serves on the Executive Committee and the Publications Committee for TOPMed.

Recent TOPMed Publications:
https://www.ncbi.nlm.nih.gov/pubmed/29973585

 

The PsychENCODE Project

 

Dr. Ashley-Koch collaborates with colleagues Dr. Greg Crawford, Greg Wray and Tim Reddy at Duke and Dr. Pat Sullivan at UNC to identify non-coding genomic variation that may contribute to risk for schizophrenia.

Recent PsychENCODE Publications:
https://www.ncbi.nlm.nih.gov/pubmed/26605881

 

Psychiatric Genomics Consortium for PTSD

Dr. Ashley-Koch is an active member of the Psychiatric Genomics Consortium. Along with her colleague, Dr. Mike Hauser, Dr. Ashley-Koch co-leads the Gene Expression Working Group for PTSD.

Recent Psychiatric Genomics Consortium for PTSD papers:
https://www.ncbi.nlm.nih.gov/pubmed/29452766
https://www.ncbi.nlm.nih.gov/pubmed/29555185
https://www.ncbi.nlm.nih.gov/pubmed/28439101
https://www.ncbi.nlm.nih.gov/pubmed/28691784

Staff

Melanie Garrett

Karen Soldano

Postdocs / Fellows

Joseph Bundy, PhD