Guofang Zhang, PhD

Faculty Member, Duke Molecular Physiology Institute

Position

Assistant Professor Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition Duke University Medical Center

Contact

Carmichael Building

919 668 2368

guofang.zhang@duke.edu

Summary

Dr. Zhang is an Assistant Professor in the Department of Medicine (Division of Endocrinology, Metabolism, and Nutrition) and Duke Molecular Physiology Institute. His research interest is on understanding the physiological/pathological mechanism of metabolic (dys)regulation using stable isotope-based metabolic flux analysis.

MS, Vrije Universiteit Brussel - Faculty of Science, Belgium

PhD, Nanjing University, China

The heart is a special organ that possesses a high efficiency of energy production system to maintain its continuous contraction (consuming ~6 kg ATP/day for a person). Disruption on cardiac energy metabolism is a risk to developing cardiomyopathy. Our current project investigatesĀ the pathological mechanism of cardiac complications associated with propionic acidemia (PA). PA is an autosomal recessive disorder caused by mutations of the PCC gene. Propionyl-CoA Carboxylase, the protein encoded by PCC, catalyzes the conversion of propionyl-CoA to methylmalonyl-CoA, which enters the TCA cycle as an anaplerotic fuel. The deficiency of PCC blocks this anaplerosis and accumulates propionyl-CoA in tissue. A quarter or higher of PA patients develop cardiac diseases which haveĀ a high mortality. Our goal is to reveal how PCC deficiency disturbs cardiac energy metabolism and induces cardiac dysfunction.

Staff

Wentao He