Jonathan Campbell is an Associate Professor in the Department of Medicine and the Department of Pharmacology & Cancer Biology. His research interests focus on the control of glucose and energy metabolism by gut-derivde peptides such as glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). This work looks to extend the recent findings demonstrating a novel pathway governed by GIP in beta cells that converges on the transcription factor Tcf1, to control beta cell function and survival. Future efforts are currently being undertaken to understand how Tcf1 controls metabolism in both pancreatic and extrapancreatic tissues. Another aspect of Dr. Campbell’s research program is to understand how gut hormones regulate energy metabolism, particularly in the context of bariatric surgery. His recent collaborative efforts demonstrated that GIP has a synergistic role when added to GLP-1 and glucagon to induce remarkable changes in body weight and glucose homeostasis, mimicking the metabolic improvements of bariatric surgery. Understanding the underlying mechanisms of these actions is the current focus of this work.
PhD York University, Toronto, Canada