Rasheed Gbadegesin, MD, MBBS

Faculty Member, Duke Molecular Physiology Institute

Position

Professor of Pediatrics and Professor in Medicine Duke University Medical Center

Contact

Carmichael Building

919 681 5543

rasheed.gbadegesin@duke.edu

Summary

Rasheed Gbadegesin, MBBS, MD is a  Professor of Pediatrics and Nephrology. Dr. Gbadegesin's research is focused on understanding the critical pathways that are involved in the pathogenesis of nephrotic syndrome and in congenital malformations of the kidney and the urinary tract. He and his group have established a phenotypic and biorepository data base for more than 600 children with hereditary and sporadic nephrotic syndrome. In the past two years they have identified two novel genes for hereditary nephrotic syndrome and vesicoureteric reflux (VUR). They have also identified a disease risk allele for childhood onset steroid sensitive nephrotic syndrome (SSNS). 

MD University of Manchester, United Kingdom
MBBS University of Ibadan, Nigeria

The major focus of our laboratory is to understand the molecular pathogenesis of nephrotic syndrome (NS) and ultimately identify novel and non-toxic therapeutic targets for the treatment of this common kidney disease. In line with this broad goal, we have been examining the molecular causes of NS and other inheritable kidney conditions using different genomic tools. In the last fifteen years, my colleagues and I have identified novel single gene causes of NS due to  focal segmental glomerulosclerosis [FSGS] (RCAN1, ANLN, ARHGAP24, COQ6, PLCE1)(1,2,3,4,5), monogenic cause of childhood steroid sensitive nephrotic syndrome SSNS (CLVS1)(6) multiple disease risk loci for SSNS(7,8,9), and a new gene for vesicoureteric reflux [VUR] (a common congenital malformation of the kidney and the urinary tract)(10). In addition, we have published multiple landmark papers on genotype phenotype correlation and papers addressing overlap between different glomerular diseases(11,12).

We and our collaborators have continued to characterize the mechanisms by which these genes can cause nephrotic syndrome, and recently identified biomarkers of disease, and druggable pathways that may treat these genetic defects and the more common idiopathic nephrotic syndrome. We are using multiple cell biology tools, iPSC derived podocytes, and kidney organoids to address these questions. In addition, we have  created a robust bio-repository for childhood nephrotic syndrome by world-wide collaboration and networking, and we are also playing a leading role in national and international networks that are unraveling the genetic basis for excess of chronic kidney diseases in people of African ancestry.

Faculty

Gentzon Hall, MD, PhD

Staff

Megan Chryst-Stangl

Guanghong Wu

Postdocs / Fellows

Rachel Cason, MD

Brandon Lane, PhD

Mital Patel, MD

Anna Williams, MD

Other Research Team Members

Lynn Rogers