Home  |  Services  |  Guidelines  |  FAQ  |  Contact Us

Established in 1996, the Molecular Genomics Core(MGC) is a state-of-the-art facility offering a variety of experimental platforms to facilitate genomics research. Accredited as a Duke Shared Resource facility in 2007, the MGC offers decades of experience with genetic, genomic and epigenomic study design and technology, working closely with researchers to customize experiments to meet their needs. The MGC highlights applications that include 10x Genomics NGS library generation for both single cell and gDNA experiments, DNA methylation microarrays, SNP genotyping and copy number microarrays, and Taqman targeted SNP genotyping.

 

 

PUBLICATION HIGHLIGHTS

Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration
Publication Authors: Emily G. O’Koren, Chen Yu, Mikael Klingeborn, Alicia Y.W. Wong,  Cameron L. Prigge, Rose Mathew, Joan Kalnitsky, Rasha A. Msallam, Aymeric Silvin, Jeremy N. Kay, Catherine Bowes Rickman, Vadim Y. Arshavsky, Florent Ginhoux, Miriam Merad, Daniel R. Saban

Non-lytic clearance of influenza B virus from infected cells preserves epithelial barrier function
Publication Authors: Rebekah E. Dumm, Jessica K. Fiege, Barbara M. Waring, Chay T. Kuo, Ryan A. Langlois & Nicholas S. Heaton

Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin
Publication Authors: Kanayama M, Xu S, Danzaki K, Gibson JR, Inoue M, Gregory SG2 Shinohara ML.

A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury.
Publication Authors: Cirulli ET, Nicoletti P, Abramson K, Andrade RJ, Bjornsson ES, Chalasani N, Fontana RJ, Hallberg P, Li YJ, Lucena MI, Long N, Molokhia M, Nelson MR, Odin JA, Pirmohamed M, Rafnar T, Serrano J, Stefansson K, Stolz A, Daly AK, Aithal GP, Watkins PB; Drug-Induced Liver Injury Network (DILIN) investigators and International DILI consortium (iDILIC)

 

ANNOUNCEMENTS

  • The DMPI Molecular Genomics Core will host talks by Olaf Hardt, PhD, Manager R&D Oncology, Miltenyi Biotec GmbH, and Nirav Patel, Technical Sales Specialist, 10X Genomics, on the Isolation of tumor cells and tumor-infiltrating lymphocytes for optimized downstream analysis and primary cell culture, and single cell solutions for genomics, transcriptomics, and epigenomics,on Thursday, March 28th 12:00-1:30 in MSRB1 room 001.

    Please see the flyer for details and RSVP at https://miltenyibiotec_10xgenomics_dukeseminar.eventbrite.com.
     

  • Be sure to download your raw scRNAseq data from the GCB for publishing. The MGC does not guarantee retention of raw sequencing data after 3 months from delivering data analysis.