The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis

In the September 5, 2017 issue of Cell Reports, Dr. Samuel Stephens, former DMPI fellow in the Newgard lab and now Assistant Professor at the Fraternal Order of Eagles Diabetes Center at the University of Iowa, reports on novel functions of the prohormone VGF in pancreatic islet beta-cells.  Dr. Stephens and co-authors show that knockout of VGF in mice impairs normal budding and maturation of beta-cell secretory granules, resulting in impaired glucose-stimulated insulin secretion and dysregulated glucose metabolism.   These studies suggest that VGF may contribute to impaired function of pancreatic islets in type 2 diabetes, a topic that Dr. Stephens is continuing to investigate in his new independent laboratory.  Congratulations and good wishes to Sam from all your friends here at DMPI!