To produce integrated multi-omics and physiologic profiles of chronic human diseases, and to use such profiles to develop new disease detection strategies, novel therapies, and insights into disease mechanisms.
Greetings from all of us at the Duke Molecular Physiology Institute (DMPI)!
Comprehensive molecular analysis of biological systems at the genomic, epigenomic, transcriptomic, proteomic, and metabolomic levels, focused by integrative computational methods, has the potential to provide a new view of the pathogenesis of chronic and pandemic human diseases and conditions. When coupled with strong clinical research capabilities, this approach can lead to innovative strategies for disease detection and intervention. The DMPI has assembled all of the component parts of such an interdisciplinary approach for disease research, and all in a new state-of-the-art research facility located in the historic tobacco district of downtown Durham, NC, minutes from the main Duke Medical Center campus. DMPI was founded in July, 2013 as a consolidation of three pre-existing units at Duke: 1) the Sarah W. Stedman Nutrition and Metabolism Center, which remains as a Center within the DMPI; 2) the Duke Center for Human Genetics, and 3) a group of clinical translational investigators, including William Kraus and Virginia Kraus as its most senior members. We highlight the venerable discipline of “physiology” in our name because it is a natural framework for integration of diverse molecular profiles. As a group, one of our strongest principles is to have the “will and skill” to interpret complex molecular profiles in a physiological context, and to use such profiles to design experiments that unveil novel biological and disease mechanisms in tractable cellular and animal model systems. Through such new mechanistic understanding, we expect to define novel methods for disease detection and targets for disease intervention that can be tested in human studies.
Please take a deeper look at what we have to offer!
Christopher B. Newgard, PhD
Director, Duke Molecular Physiology Institute