Member of Duke Molecular Physiology Institute
Opeyemi Olabisi, MD, PhD is an Assistant Professor in the Department of Medicine, Division of Nephrology. Dr. Olabisi utilizes patient-stem cell-derived podocytes and reprogrammed mammalian cell lines as tools for uncovering disease mechanisms of APOL1 nephropathy.
MD. Albert Einstein College of Medicine
PhD, Albert Einstein College of Medicine
The focus of my research is to delineate the mechanism by which kidney disease risk variants in APOL1 accelerate the progression of kidney disease in humans. We found that induced expression of APOL1 kidney disease variants in cell culture is associated with increased loss of cellular potassium and dysregulation of signaling pathways known to cause kidney failure. The ultimate goal of my research is to extend these findings and translate them into improved diagnostic and treatment approaches to chronic kidney disease.
Using APOL1 transgenic cell lines, transgenic APOL1 mice and specific chemical inhibitors, we aim to fully characterize the effects of APOL1 risk variants on normal cellular signaling pathways. These robust systems will enable us to answer the question of how APOL1 risk variants result in cell death, and what protective mechanisms shield certain cells from APOL1 toxicity.
As an initial step towards translating our findings to human kidney disease, we collaborate with nephrologists and pathologists nationwide who provide us with kidney biopsy samples from individuals with APOL1 nephropathy. These biopsy samples provide us with a platform for validating relevant signaling pathways discovered in cell culture and transgenic mice.
Somenath Datta, PhD
Senior Research Associate
Guojie Li, PhD
Sarah Nystrom, MD, MPH
Nephrology Research Fellow
Senior Lab Research Analyst
Senior Clinical Research Coordinator
Research Technician II
THE APOL1 STUDY AT DUKE HEALTH
- Received a 5-year R01 grant from NIMHD to conduct APOL1 clinical trial in the Durham community, as well as clinical trial-in-the-dish (October 2021)
- Dr. Olabisi Receives Rising Star Award at Alma Mater
- Opeyemi Olabisi Receives NIH New Innovator Award
- Selection as a Whitehead Scholar
- Welcome Dr. Opeyemi Olabisi