Integration of metabolomic and transcriptomic analyses reveals novel regulatory functions of the ChREBP transcription factor
Genetic epidemiology studies of chronic kidney diseases (CKD) in West Africa showed a single risk allele of the APOL1 gene is clearly associated with CKD, while the high-risk APOL1 genotype has a prevalence of up to 50% in some African populations
Ketone flux through BDH1 supports metabolic remodeling of skeletal and cardiac muscles in response to intermittent time-restricted feeding
APOL1 G1 and G2 variants cause kidney disease by increasing Na+/K+ transport across the plasma membrane of podocytes
- Integration of metabolomic and transcriptomic analyses reveals novel regulatory functions of the ChREBP transcription factor
- Genetic epidemiology studies of chronic kidney diseases (CKD) in West Africa showed a single risk allele of the APOL1 gene is clearly associated with CKD, while the high-risk APOL1 genotype has a prevalence of up to 50% in some African populations
- Ketone flux through BDH1 supports metabolic remodeling of skeletal and cardiac muscles in response to intermittent time-restricted feeding
- APOL1 G1 and G2 variants cause kidney disease by increasing Na+/K+ transport across the plasma membrane of podocytes
DUKE MOLECULAR PHYSIOLOGY INSTITUTE
Our mission is to produce integrated multi-omics and physiologic profiles of chronic human diseases, and to use such profiles to develop new disease detection strategies, novel therapies, and insights into disease mechanisms.
An integrative approach for innovative discoveries
DMPI RESEARCH SECTIONS
DMPI NEWS
UPCOMING EVENTS
September 16
4:00 pm to 5:00 pm
October 7
4:00 pm to 5:00 pm