Retrotranslation of metabolomic signatures of mitochondrial overload to underlying mitochondrial biology
More than a decade ago, DMPI faculty members Drs. Debbie Muoio and Tim Koves teamed with Drs. Robert Stevens, Olga Ilkayeva, and James Bain in the DMPI metabolomics lab to report on accumulation of incompletely oxidized lipid species (in the form of even-chain acylcarnitines) in skeletal muscle of obese and insulin resistant rodents and humans