Established in 1996, the Molecular Genomics Core (MGC) is a state-of-the-art facility offering a variety of experimental platforms to facilitate (epi)genomics and proteomics research. Accredited as a Duke Core facility in 2007, the MGC offers decades of experience with genetic, genomic, epigenomic and proteomic study design and technology, and works closely with researchers to customize experiments to meet their needs. The MGC highlights applications that include 10x Genomics single-cell library (Chromium) for both gene expression and ATAC sequencing and spatial gene expression (Visium) platforms, DNA methylation microarrays, SNP genotyping and copy number microarrays, and Taqman targeted SNP genotyping. We have also recently implemented the Quanterix Simoa® bead-based immunoassay technology which is capable of detecting proteins at femtogram levels in serum and plasma.